There are seven changes to the side that recorded a bonus-point victory away to Ulster last week.
Ireland utility forward Beirne returns to lead the home side with Rory Scannell, Billy Burns, Ethan Coughlan, Dian Bleuler, Oli Jager and Alex Kendellen also coming into the starting XV.
Positional switch for Tom Ahern
There is also a positional switch for Tom Ahern as he moves to the back-row.
Meanwhile, Mike Haley, Calvin Nash and Shane Daly form an unchanged back three with Rory Scannell and last week’s Player of the Match Tom Farrell lining up in midfield.
Coughlan and Burns start together in the half-backs.
Bleuler has completed the return-to-play protocols to make his fourth start at loosehead prop with Niall Scannell and Oli Jager completing the front-row.
Fineen Wycherley and Beirne start in the engine room with Ahern, Alex Kendellen and Gavin Coombes completing the starting XV.
Diarmuid Barron, Academy prop Kieran Ryan and John Ryan provide the front-row back-up with Brian Gleeson and John Hodnett completing the forward cover.
Paddy Patterson, Tony Butler and Munster Academy back-three player Ben O’Connor are the backline replacements.
On the injury front, Peter O’Mahony (calf contusion), Conor Murray (elbow) and Jack O’Donoghue (shoulder) were unavailable for selection.
In line with IRFU player management guidelines, Jack Crowley was unavailable for selection.
Ireland skipper returns for Leinster
Meanwhile, Leinster have also received a boost with the news that Ireland captain Caelan Doris is back into the mix to skipper his province against their arch-rivals this crunch URC derby.
Leinster head coach Leo Cullen has made a number of changes from the squad that beat Connacht in front of nearly 34,000 at Aviva Stadium last weekend.
Jamie Osborne makes a welcome return from injury and starts at full-back, with Tommy O’Brien and Jimmy O’Br
ien lining up on the wings.
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